Scientists develop a cheap, smartphone-based test for Zikaand it could be a game-changer

Scientists develop a cheap, smartphone-based test for Zikaand it could be a game-changer

Many a world traveler questioned their tropical vacation plans last year after the mosquito-borne Zika virus started making headlines. To test for the disease, which has been tied to a surge ofmicrocephaly cases in infants, physicians look for flu-like symptoms and your recent travel history. They then confirm a diagnosis by testinga blood or urine sample. For modern Westerntravelers, that’s no big deal. But what about those who may not be able to afford a doctor’slab tests or clinics unable to afford costly testing equipment in the first place?

Researchers at Sandia National Labs have come up with adiagnostic test for Zika that’s smaller and cheaper than current testing equipment. In fact, it’s based arounda smartphone. Like existing tests,ithinges ona blood sample, but then the blood isput through a process calledloop-mediated isothermal amplification (LAMP). In this process, a sample mixed with“a few carefully designed biochemical agents” is heated to 150 degrees Fahrenheit for 30 minutes. Any positive DNA fragmentsin the sample will glow,tagged by a light emittingfluorophore molecule. To check for those positive, glowing reactions, yoursmartphone (situated over the LAMP box) performs some image recognition using its camera and a dedicated app.

This technique is leagues cheaper than current testing solutions, whose equipmentcan cost upwards of $20,000. That equipment also tends to be quite large, which, while appropriate for laboratories, isn’t ideal for small clinics. A prototype of thisLAMP box, by contrast, can be held in one hand. It’s also faster, with the process only taking half an hour.

Photo via Sandia National Laboratories

Lead paper author Aashish Priye holding the Zika box prototype, with Sara Bird (center), a virologist, and Cameron Ball, a biomedical engineer.

“There are billions of smartphones in the world, even in developing countries, and this tool doesnt require the highest-end smartphone on the market, chemical engineer and paper lead author Aashish Priye said. It only needs to have an optical sensor and be able to run the app.

This solution is just one of a growing number of lab tests and medical diagnostic tools that are moving to the smartphone. For example, in 2014, researchers at the University of Cambridge developed an app that paired with testing strips to monitor a variety of medical conditions. And in 2015, Columbia University researchers developed amobile-based lab-on-a-chip that could check for HIV and syphilis in only 15 minutesand cost only $34. Armed with a suite of relatively cheap accessories, physicians working in remote locations could perform a variety of useful, accurate tests minus the lab (and with a fraction of the legwork).

In this case, the app and LAMP box could be used to check not only forZikabut also dengue and chikungunya. These diseases are all spread by the same type of mosquito and result in similar symptoms.Outfitted with these types of tools, clinicians will hopefully be able to identify and treat pandemic threats more quickly and more successfully in the near future.

Read more: https://www.dailydot.com/debug/zika-virus-testing-smartphone-app/

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